Cellular Senescence and Inflammaging in the Skin Microenvironment

Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD.

Histone deacetylase 2 (HDAC2) is a class I histone deacetylase that regulates various cellular processes, such as cell cycle, senescence, proliferation, differentiation, development, apoptosis, and glucocorticoid function in inhibiting inflammatory response. HDAC2 has been shown to protect against DNA damage response and cellular senescence/premature aging via an epigenetic mechanism in respons...

Microarraying the cellular microenvironment

The in vivo stem cell microenvironment or niche is composed of an intricate blend of extracellular matrix proteins, soluble protein factors, immobilized protein factors, proteoglycans, small molecule signals, in some cases mineralized tissue, and numerous adjacent cell types, all of which likely vary in space and time. In concert, these many components present the cells with an ‘array’ of bioch...

Patterning the cellular microenvironment.

Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin

Cellular senescence arrests the proliferation of mammalian cells at risk for neoplastic transformation, and is also associated with aging. However, the factors that cause cellular senescence during aging are unclear. Excessive reactive oxygen species (ROS) have been shown to cause cellular senescence in culture, and accumulated molecular damage due to mitochondrial ROS has long been thought to ...

In Vitro Evaluation of Protective Effect of Rutin on Acrylamide-Induced Cellular Senescence in NIH3T3 Cells

Background: Aging is one of the important factors in the development of age-related diseases. Acrylamide can be produced during carbohydrate-rich foods prepared at high temperatures. Recently, studies showed that acrylamide can induce cellular senescence. On the other hand, Rutin as a natural flavonoid, has a potent antioxidant activity. Objective: This study aims to evaluate the ptotective ef...