Cellular Senescence Is Associated With Human Retinal Microaneurysm Formation During Aging
نویسندگان
چکیده
منابع مشابه
Aging, cellular senescence, and cancer.
For most species, aging promotes a host of degenerative pathologies that are characterized by debilitating losses of tissue or cellular function. However, especially among vertebrates, aging also promotes hyperplastic pathologies, the most deadly of which is cancer. In contrast to the loss of function that characterizes degenerating cells and tissues, malignant (cancerous) cells must acquire ne...
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Institute for Research and Innovation in Health (i3s), University of Porto, 4200-135 Porto, Portugal Department of Biomedicine, Unit of Biochemistry, Faculty of Medicine of the University of Porto (FMUP), 4200-319 Porto, Portugal Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge CB2 0SW, UK Department of Biomedicine, Unit of Experimental Biology, Faculty of Medicine o...
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Increased levels of oxidized proteins with aging have been considered a cardiovascular risk factor. However, it is unclear whether oxidized albumin, which is the most abundant serum protein, induces endothelial damage. The results of this study indicated that with aging processes, the levels of oxidized proteins as well as endothelial microparticles release increased, a novel marker of endothel...
متن کاملCellular senescence in aging primates.
The aging of organisms is characterized by a gradual functional decline of all organ systems. Mammalian somatic cells in culture display a limited proliferative life span, at the end of which they undergo an irreversible cell cycle arrest known as replicative senescence. Whether cellular senescence contributes to organismal aging has been controversial. We investigated telomere dysfunction, a r...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2017
ISSN: 1552-5783
DOI: 10.1167/iovs.16-20312