Cerebellar fastigial nucleus: from anatomic construction to physiological functions
نویسندگان
چکیده
منابع مشابه
Cerebellar fastigial nucleus influence on ipsilateral abducens activity during saccades.
To characterize the cerebellar influence on neurons in the abducens (ABD) nucleus, we recorded ABD neurons before and after we inactivated the caudal part of the ipsilateral cerebellar fastigial nucleus (cFN) with muscimol injection. cFN activity influences the horizontal component of saccades. cFN inactivation increased the activity of most ipsilateral ABD neurons (19/22 in 2 monkeys) during i...
متن کاملElectro-stimulation of cerebellar fastigial nucleus (FNS) improves axonal regeneration.
This study focused on the effect of electro-stimulation of fastigial nucleus on the expression of NgR and on axonal regeneration after focal cerebral ischemia-reperfusion in rats. Cerebral ischemia and reperfusion was induced by nylon monofilament. Ninety-six male SD rats were randomly divided into sham group and ischemic insult groups at 12 hours, 24 hours, and 1 to 3 weeks after cerebral isch...
متن کاملDissociation by chloralose of the cardiovascular and cerebrovascular responses evoked from the cerebellar fastigial nucleus.
We studied the effects of chloralose anesthesia on the elevation in arterial pressure (AP), heart rate (HR), and regional CBF (rCBF) elicited by stimulation of the cerebellar fastigial nucleus (FN). Rats were anesthetized with an initial dose of chloralose (40 mg/kg s.c.), paralyzed, and artificially ventilated. The FN was stimulated (50-100 microA, 50 Hz, 1 s on/1 s off) with microelectrodes s...
متن کاملIntegrity of Cerebellar Fastigial Nucleus Intrinsic Neurons Is Critical for the Global Ischemic Preconditioning
Excitation of intrinsic neurons of cerebellar fastigial nucleus (FN) renders brain tolerant to local and global ischemia. This effect reaches a maximum 72 h after the stimulation and lasts over 10 days. Comparable neuroprotection is observed following sublethal global brain ischemia, a phenomenon known as preconditioning. We hypothesized that FN may participate in the mechanisms of ischemic pre...
متن کاملStimulation of cerebellar fastigial nucleus inhibits interleukin-1β-induced cerebrovascular inflammation.
Electrical stimulation of the cerebellar fastigial nucleus (FN) in rat protects the brain against ischemia. We studied whether FN could reduce the cerebrovascular inflammation as a mechanism of protection. FN or dentate nucleus (sham controls) was electrically stimulated for 1 h, and 72 h later rats were either injected with interleukin (IL)-1β into the striata or processed to analyze inflammat...
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ژورنال
عنوان ژورنال: Cerebellum & Ataxias
سال: 2016
ISSN: 2053-8871
DOI: 10.1186/s40673-016-0047-1