Cerebral Microvascular Injury in Traumatic Brain Injury

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Cerebral Microvascular Injury in Traumatic Brain Injury

Traumatic cerebral vascular injury (TCVI) is a frequent, perhaps universal, feature after traumatic brain injury (TBI) and may be responsible for for some TBI-related chronic disabilities. Because there are multiple pharmacologic and non-pharmacologic therapies that promote vascular health, TCVI is an attractive target for therapeutic intervention after TBI. The cerebral microvasculature (CMV) ...

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Microglia is one of the first innate immune components. These cells account about 5 to 10% of the entire adult brain cells and are activated by trauma. Complex-mediated inflammatory responses occur through cellular and molecular events during and after the traumatic brain injury (TBI). In-lesion area astrocytes, microglia, and damaged neurons begin to secrete cytokines and chemokines. Microglia...

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Vasospasm following traumatic brain injury (TBI) may dramatically affect the neurological and functional recovery of a vulnerable patient population. While the reported incidence of traumatic vasospasm ranges from 19%-68%, the true incidence remains unknown due to variability in protocols for its detection. Only 3.9%-16.6% of patients exhibit clinical deficits. Compared to vasospasm resulting f...

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ژورنال

عنوان ژورنال: Journal of Neurology and Neuromedicine

سال: 2016

ISSN: 2572-942X

DOI: 10.29245/2572.942x/2016/6.1067