Cfp1 is required for gene expression dependent H3K4me3 and H3K9 acetylation in embryonic stem cells
نویسندگان
چکیده
منابع مشابه
Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells.
Trimethylation of histone H3 Lys 4 (H3K4me3) is a mark of active and poised promoters. The Set1 complex is responsible for most somatic H3K4me3 and contains the conserved subunit CxxC finger protein 1 (Cfp1), which binds to unmethylated CpGs and links H3K4me3 with CpG islands (CGIs). Here we report that Cfp1 plays unanticipated roles in organizing genome-wide H3K4me3 in embryonic stem cells. Cf...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2014
ISSN: 1465-6906
DOI: 10.1186/preaccept-8577431391252814