Changes in cerebral oxygenation and cognitive functions during controlled hypotension

Purpose: This study aimed to evaluate the effect of controlled hypotension on cerebral oxygen saturation and postoperative cognitive dysfunction (POCD) in patients undergoing nasal surgery.
 Materials Methods: Forty were randomized by a sealed envelope method into two drug groups: esmolol (Group E, n=20) or nitroglycerin N, administration prior surgical incision. The functions evaluated Mini-Mental State Examination Test 1 day before after operation. Regional was monitored with near-infrared spectroscopy detect desaturation.
 Results: desired mean arterial blood pressure (50-65 mmHg) could be achieved all groups. A decline function occured 16 (40%) at 24th hour. There no statistically significant difference between groups terms POCD. relationship POCD desaturation status. 
 Conclusion: Cerebral seen during hypotensive anesthesia may cause early development, therefore we think that close hemodynamic monitoring preserve functions.