Changes in pericardial morphology and fibrinolytic activity during cardiopulmonary bypass

Pupil changes during cardiopulmonary bypass.

Pupil diameter is used during anaesthesia to assess depth of anaesthesia and indicate cerebral hypoxia. This is especially so during cardiac bypass when other autonomic signs cannot be monitored. We have used a pupillometer to determine the effect of cardiopulmonary bypass on the pupil. We have also investigated if any effect was caused by washout of opioid from the central nervous system by al...

Does the type of surgical operation influence the changes observed in fibrinolytic activity after cardiopulmonary bypass?

Embolic activity during in vivo cardiopulmonary bypass.

Neurologic injury after cardiac surgery is principally associated with emboli. Although much work has focused on surgical sources of emboli, less attention has been focused on emboli associated with the heart-lung machine. We tested whether emboli are associated with discrete processes during cardiopulmonary bypass (CPB). One hundred patients undergoing cardiothoracic surgery were enrolled betw...

Changes in Fibrinolytic Activity during Surgical Procedures.

Hypoxaemia during cardiopulmonary bypass.

For cardiopulmonary bypass during open-heart surgery we use a bubble oxygenator and a technique of haemodilution and moderate hypothermia. During the course of routine perfusion we have observed arterial desaturation in a number of patients and in five patients the desaturation was marked (SaO2<85%)'. The low arterial oxygen saturations occurred mainly in the rewarming period. This report is of...