Changes in the Intestinal Microbiota in Patients with Chronic Pancreatitis: Systematizing Literature Data

The purpose of the review. To systematize literature data on changes in structure intestinal microbiota patients with chronic pancreatitis (CP). Key findings. human is a dynamically changing system that constantly undergoing qualitative and quantitative changes, especially several pathological conditions digestive system. At present, differences pancreatic diseases are poorly understood. severe CP associated impaired synthesis antimicrobial peptides, bicarbonates, enzymes by pancreas, which risk factor for dysbiotic microbiota, consisting development small bacterial overgrowth (SIBO) gut dysbiosis. results two large meta-analyses show about third have SIBO. colonic also characterized disorders, primarily reduction alpha-diversity. Some studies shown these an increase Firmicutes , while Bacteroides Faecalibacterium reduced. In addition, as rule, CP, growth Escherichia Shigella Streptococcus recorded. Conclusion. general, scientific papers revealed significant heterogeneity profiles CP. Thus, questions remain open, prioritizing further study identifying specifics its can personalize selection enzyme replacement therapy restrict unreasonable prescription additional pharmacotherapy (the use proton pump inhibitors / or antibacterial drugs).