Channel-like slippage modes in the human anion/proton exchanger ClC-4
                    
                        
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منابع مشابه
Channel-like slippage modes in the human anion/proton exchanger ClC-4
The ClC family encompasses two classes of proteins with distinct transport functions: anion channels and transporters. ClC-type transporters usually mediate secondary active anion-proton exchange. However, under certain conditions they assume slippage mode behavior in which proton and anion transport are uncoupled, resulting in passive anion fluxes without associated proton movements. Here, we ...
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UNLABELLED Glomerular protein handling mechanisms have received much attention in studies of nephrotic syndrome. Histopathological findings in renal biopsies from severely proteinuric patients support the likelihood of protein endocytosis by podocytes. ClC-5 is involved in the endocytosis of albumin in the proximal tubule. AIM To investigate whether ClC-5 is expressed in the glomerular compar...
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CLC-ec1, a bacterial homologue of the CLC family's transporter subclass, catalyzes transmembrane exchange of Cl(-) and H(+). Mutational analysis based on the known structure reveals several key residues required for coupling H(+) to the stoichiometric countermovement of Cl(-). E148 (Glu(ex)) transfers protons between extracellular water and the protein interior, and E203 (Glu(in)) is thought to...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2009
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.200810155