Channeling During Prothrombin Activation
نویسندگان
چکیده
منابع مشابه
Human prothrombin activation.
Human prothrombin has been purified from American Red Cross Factor IX concentrates. Studies of the activation of the human prothrombin with the use of sodium dodecyl sulfate electrophoretic analysis of activation products indicated that human prothrombin activation is similar to bovine prothrombin activation. Molecular weight analysis of human prothrombin and intermediated by sodium dodecyl sul...
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Energetic positrons propagating along low index directions in a crystal interact strongly with the periodic array of atoms via a process known as channeling. The trajectories of such channeled positrons can be manipulated to sample dierent spatial regions in the crystal. Here we report the ®rst observations of channeling eects on in̄ight annihilation radiation from positrons traversing a thin ...
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The kinetics of the activation of human prothrombin catalyzed by human prothrombinase was studied using the fluorescent a-thrombin inhibitor dansylarginineN-(3-ethyl-1,5-pentanediyl)amide(DAPA). Prothrombinase proteolytically activates prothrombin to athrombin by cleavages at Arg273-Thr274 (bond A) and Arg322-Ile323 (bond B). The differential fluorescence properties of DAPA complexed with the...
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The effects on platelet aggregation of native rat chyle chylomicrons, chylomicron remnants, and chylomicrons that had been preincubated with rat or human EDTA-plasma, serum, whole blood, or pure human prothrombin were examined. The native chyle chylomicrons did not induce platelet aggregation but decreased ADP- and thrombin-induced platelet aggregation and [14C]serotonin release. Chylomicron re...
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The prothrombinase complex converts prothrombin to α-thrombin through the intermediate meizothrombin (Mz-IIa). Both α-thrombin and Mz-IIa catalyze factor (F) XI activation to FXIa, which sustains α-thrombin production through activation of FIX. The interaction with FXI is thought to involve thrombin anion binding exosite (ABE) I. α-Thrombin can undergo additional proteolysis to β-thrombin and γ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m101813200