Characterisation of colonic dysplasia-like epithelial atypia in murine colitis

Characterisation of colonic dysplasia-like epithelial atypia in murine colitis

AIM To determine if exacerbation of pre-existing chronic colitis in Winnie (Muc2 mutant) mice induces colonic dysplasia. METHODS Winnie mice and C57BL6 as a genotype control, were administered 1% w/v dextran sulphate sodium (DSS) orally, followed by drinking water alone in week-long cycles for a total of three cycles. After the third cycle, mice were killed and colonic tissue collected for hi...

Colonic epithelial metabolism in ulcerative colitis.

Epithelial Dysplasia in Oral Cavity (Review Article)

Among oral lesions, we encounter a series of malignant epithelial lesions that go through clinical and histopathologic processes in order to be diagnosed. Identifying these processes along with the etiology knowledge of these lesions is very important in prevention and early treatments. Dysplasia is the step preceding the formation of squamous cell carcinoma in lesions which have the potential ...

Proliferative colitis in ferrets: epithelial dysplasia and translocation.

4 Harmon BG, Adams LG, Frey M: Survival of rough and smooth strains of Brucella abortus in bovine mammary gland macrophages. Am J Vet Res 49:1092-1097, 1988 5 Karlsbad G, Kessel RWI, dePetris S, Monaco L: Electron microscopic observations of Brucella abortus grown within monocytes in vitro. J Gen Microbiol35:383-390, 1964 6 Meador VP, Tabatabai LB, Hagemoser WA, Deyoe BL: Identification of Bruc...

Role of far upstream element binding protein 1 in colonic epithelial disruption during dextran sulphate sodium-induced murine colitis.

AIM Intestinal epithelial barrier is essential for maintaining normal intestinal homeostasis; its breakdown leads to chronic inflammatory pathologies, such as inflammatory bowel diseases. Far upstream element binding protein 1 (FBP1) has been reported to play an important role in cell apoptosis and proliferation. We aimed to investigate the expression and the role of FBP1 in dextran sodium sulp...