Characterisation of OXA-51, a novel class D carbapenemase found in genetically unrelated clinical strains of Acinetobacter baumannii from Argentina
نویسندگان
چکیده
منابع مشابه
molecular detection of class-d oxa carbapenemase genes in biofilm and non-biofilm forming clinical isolates of acinetobacter baumannii
conclusions coexistence of the blaoxa-51, blaoxa-23 and blaoxa-24/40 like genes, along with formation of strong biofilm, in mdr-ab strains particularly with indiscriminate use of imipenem, complicated treatment of the patients infected with these bacteria in the hospitals understudy. background emergence and spread of carbapenemase (blaoxa) genes in multidrug resistant acinetobacter baumannii (...
متن کاملMolecular Detection of Class-D OXA Carbapenemase Genes in Biofilm and Non-Biofilm Forming Clinical Isolates of Acinetobacter baumannii
BACKGROUND Emergence and spread of carbapenemase (bla OXA) genes in multidrug resistant Acinetobacter baumannii (MDR-AB) forming biofilm complicated treatment of the patients infected with this microorganism particularly in intensive care units (ICUs). OBJECTIVES The current study aimed to determine the prevalence of molecular class-D OXA carbapenemase in biofilm and non-biofilm forming strai...
متن کاملOXA-58, a novel class D {beta}-lactamase involved in resistance to carbapenems in Acinetobacter baumannii.
A carbapenem-resistant Acinetobacter baumannii strain was isolated in Toulouse, France, in 2003. Cloning and expression in Escherichia coli identified the carbapenem-hydrolyzing beta-lactamase OXA-58, which is weakly related (less than 50% amino acid identity) to other oxacillinases. It hydrolyzed penicillins, oxacillin, and imipenem but not expanded-spectrum cephalosporins. The bla(OXA-58) gen...
متن کاملPolyclonal spread of bla(OXA-23) and bla(OXA-58) in Acinetobacter baumannii isolates from Argentina.
BACKGROUND In order to study the enzymatic carbapenem resistance mechanisms in Acinetobacter baumannii isolates from Argentina, we performed molecular characterization on 41 epidemiologically unrelated strains isolated from 1995 to 2006 with diminished susceptibilities to imipenem and meropenem. METHODOLOGY Acinetobacter baumannii isolates were identified with the ARDRA technique. The total g...
متن کاملMultidrug-Resistant Acinetobacter baumannii Harboring OXA-24 Carbapenemase, Spain
In February 2006, a patient colonized with a multidrug-resistant sequence type 56 Acinetobacter baumannii strain was admitted to a hospital in Madrid, Spain. This strain spread rapidly and caused a large outbreak in the hospital. Clinicians should be alert for this strain because its spread would have serious health consequences.
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ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 2005
ISSN: 1198-743X
DOI: 10.1111/j.1469-0691.2004.01016.x