Characterisation of transcriptionally active and inactive chromatin domains in neurons
نویسندگان
چکیده
منابع مشابه
Characterisation of transcriptionally active and inactive chromatin domains in neurons.
The tandemly organised ribosomal DNA (rDNA) repeats are transcribed by a dedicated RNA polymerase in a specialised nuclear compartment, the nucleolus. There appears to be an intimate link between the maintenance of nucleolar structure and the presence of heterochromatic chromatin domains. This is particularly evident in many large neurons, where a single nucleolus is present, which is separated...
متن کاملOrganization of Transcriptionally Active and Inactive Chromatin
Der Aufbau des Nukleosoms als Grundbaustein des Chromatins der Eukaryontenzelle, mit Ausnahme des Dinoflagellaten-Zellkerns, wird biochemisch und elektronenmikroskopisch vorgestellt als eine Einheit eines Oktamers aus Histonen (2 X H2A, 2XH2B, 2X H3, 2X H4) und einem Betrag von etwa 150 Basenpaaren DNA. Diese Partikel sind durch einen Zwischenbereich von weiteren etwa 50 Basenpaaren DNA verbund...
متن کاملStructure of transcriptionally active chromatin.
Rat-liver chromatin has bee fractionated into transcriptionally active and inactive regions [Gottesfeld et al. (1974) Proc. Nat. Acad. Sci. USA 71, 2193-2197] and the distribution of nuclease-resistant complexes in these fractions has been investigated. About half of the DNA of both fractions is resistant to attack by tne endonuclease DNase II. The nuclease-resistant structures of inactive chro...
متن کاملOncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains.
In a subset of poorly differentiated and highly aggressive carcinoma, a chromosomal translocation, t(15;19)(q13;p13), results in an in-frame fusion of the double bromodomain protein, BRD4, with a testis-specific protein of unknown function, NUT (nuclear protein in testis). In this study, we show that, after binding to acetylated chromatin through BRD4 bromodomains, the NUT moiety of the fusion ...
متن کاملProteins of transcriptionally active and inactive chromatin from Friend erythroleukemia cells.
Transcriptionally active and inactive chromatin fractions were prepared from control and dimethyl sulfoxide (DMSO)-treated murine erythroleukemia cells by the DNase II technique of Gottesfeld et al. (Proc natl acad sci US 71 (1974) 2193). The active and inactive chromatin fractions from control and DMSO-treated cells had essentially the same total histone content, but the active chromatin fract...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2000
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.113.24.4463