Characterising deviation from treat-to-target strategies for early rheumatoid arthritis: the first three years
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چکیده
منابع مشابه
Characterising deviation from treat-to-target strategies for early rheumatoid arthritis: the first three years
INTRODUCTION Treat-to-target (T2T) strategies using a protocol of pre-defined adjustments of disease-modifying anti-rheumatic drugs (DMARDs) according to disease activity improve outcomes for patients with rheumatoid arthritis (RA). However, successful implementation may be limited by deviations from the protocol. The aim of this study was to determine the prevalence of protocol deviation, expl...
متن کاملIncorporating the treat-to-target concept in rheumatoid arthritis.
BACKGROUND Recent publications have proposed revisions to disease classification criteria, new definitions of remission, and guidelines for implementing treat-to-target strategies for the management of patients with rheumatoid arthritis (RA). Despite developments leading to this practice-changing approach, the concept of treat to target has not yet been widely accepted or implemented in managed...
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Treating rheumatoid arthritis (RA) with a goal or «Treat to target» strategy is a therapeutic proposal taken from cardiovascular and endocrine literature. It proposes that the therapeutic target in RA should be a state of remission, or an alternative goal could be a low disease activity. Rheumatologists should measure and register disease activity in every clinical visit and if the goal has not...
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OBJECTIVE Treat-to-target (T2T) leads to improved clinical outcomes in early rheumatoid arthritis (RA). The question is whether these results sustain in the long term. Our objective was to investigate the 3-year results of a protocolized T2T strategy in daily clinical practice. METHODS In the Dutch Rheumatoid Arthritis Monitoring remission induction cohort, patients newly diagnosed with RA we...
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R e u m a t o i d a r t h r i t i s ( R A) i s a chronic inflammatory polyarticular autoimmune disease affecting 0.4-1 % of general population. I t causes cartilage destruction and bony erosions in synovial jo ints . Act ivat ion of T lymphocytes by unknown antigens, stimulates monocytes, macrophages and synovial fibroblasts to produce cytokines, interleukin 1, 6 and TNF α in the synovial fluid...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2015
ISSN: 1478-6354
DOI: 10.1186/s13075-015-0562-0