Characterization And Cytotoxicity of Novel Synthesis Selenium Nanoparticles Stabilized By Vitamin E TPGS

The aim of this research was to investigate synergistic effect combination two related antioxidant agents by novel synthesis selenium nanoparticles functionalized with D-α- Tocopherol polyethylene glycol 1000 succinate (TPGS) as a capping agent during chemical reduction sodium selenite ascorbic acid. Particle size, morphology, crystallite size synthesized Se-TPGS were characterized dynamic light scattering (DLS), transmission electron microscopy (TEM), Field Emission Scanning Electron Microscopy (FESEM), Ultraviolet-Visible spectrophotometry (UV/Vis), X-Ray diffraction (XRD). in vitro activity, cell toxicity and blood compatibility assays respectively. DLS results revealed that the possess very low polydispersity index value (PDI = 0.03) having hydrodynamic particle 83.33 ± 14.7 nm negatively for zeta potential equal -19.5 mV. Both SEM TEM show regular spherical shape SeNPs measurement less than measuring. XRD result confirming produced possessed standard crystalline hexagonal phase structure. DPPH assay total activity display high NPs when comparing acid reference material. cytotoxicity new formula investigated both cancerous (MCF-7) normal (HBL-100) breast lines significantly different. This study provides facile green method chemically synthesizing stable which are suitable further evaluation therapeutic applications. could be blueprint field biomedical application an alternative chemotherapy fighting cells.