Characterization and Neutralization of Pathologic Memory CD4 +T Cells in Spondyloarthritis Synovial Fluid

Abstract Spondyloarthritis (SpA), which has increased T helper 17 (Th17) cell activity, and neutralizing antibodies targeting IL-17 are effective in patients with SpA. However, not all Th17 cells pathologic; most have physiological roles. Here, we characterize the immune landscape of blood synovial SpA through single to demonstrate molecular characteristics pathologic memory CD4 +T characters. We identified (pTh17) as polyfunctional IL-17A IFN-γ-producing cells, clinically supporting evidence for their pathogenic roles at inflammatory site Transcriptome flow cytometric analysis found that co-expression TNFRSF4 TNFRSF18 is pTh17 cells. Suppression ligand-receptor interactions via effectively decreased clinical arthritis curdlan-injected SKG mouse model. Our results provide understanding suggest potential therapeutic targets.