Characterization of 3-Dimensional PET Systems for Accurate Quantification of Myocardial Blood Flow
نویسندگان
چکیده
منابع مشابه
BASIC SCIENCE INVESTIGATIONS Absolute Quantification of Myocardial Blood Flow with H2O and 3-Dimensional PET: An Experimental Validation
The purpose of this study was to assess a 3-dimensional (3D)– only PET scanner (ECAT EXACT3D) for its use in the absolute quantification of myocardial blood flow (MBF) using H2O. Methods: Nine large white pigs were scanned with H2O and C15O before and after partially occluding the circumflex (n 4) or the left anterior descending (n 5) coronary artery at rest and during hyperemia induced by intr...
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UNLABELLED (15)O-Water and dynamic PET allow noninvasive quantification of myocardial blood flow (MBF). However, complicated image analyzing procedures are required, which may limit the practicality of this approach. We have designed a new practical algorithm, which allows stable, rapid, and automated quantification of regional MBF (rMBF) using (15)O-water PET. We designed an algorithm for sett...
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Materials and methods Maximal flow velocities (Vmax) and flow volumes (SV) were quantified by 2D and 4D VEC MRI in healthy volunteers (n=7) and patients with aortic (n=7) or pulmonary valve stenosis (n=10). Measurements were performed immediately above the aortic or pulmonary valve (=level 1). Using 4D VEC MRI additional measurements were performed at 3 further levels in the ascending aorta (le...
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H2O as a PET-tracer offers the opportunity to examine perfusion of blood into tissue non-invasively (cf. [1]). It features a short radioactive half-life (≈ 2 min.) and therefore adds a smaller radiation exposure to the patient in comparison to other tracers. The disadvantages arising from the short radioactive half-life are noisy, low-resolution reconstructions. Previous algorithms first recons...
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ژورنال
عنوان ژورنال: Journal of Nuclear Medicine
سال: 2016
ISSN: 0161-5505,2159-662X
DOI: 10.2967/jnumed.116.174565