Characterization of a gp91-phox Promoter Element That Is Required for Interferon γ-induced Transcription
نویسندگان
چکیده
منابع مشابه
JAK2 is necessary and sufficient for interferon- -induced transcription of the gene encoding gp91
During the inflammatory response, interferon(IFN) increases transcription of the gene encoding gp91, a respiratory burst oxidase component. This gene (referred to as the CYBB gene) is transcribed in phagocytic cells differentiated beyond the promyelocyte stage, and transcription continues until cell death. Previous investigations identified a positive regulatory element in the proximal CYBB pro...
متن کاملInterferon regulatory factor-2 directs transcription from the gp91phox promoter.
Repressor elements in the gp91(phox) promoter are necessary to restrict tissue-specific transcription to mature phagocytes. Deletion of these elements leads to significant promoter activity in cell lines such as HEL and K562 that do not normally express gp91(phox). The -100 to +12 base pair gp91(phox) promoter region is sufficient to direct maximal de-repressed transcription in these cells. How...
متن کاملCharacterization of a promoter element required for transcription in myocardial cells.
Transcription of the chicken cardiac troponin T (cTNT) gene in myocardial cells requires upstream sequences not required for expression of this gene in embryonic skeletal muscle cells. Deletion analysis shows that the segment between nucleotides -247 and -201 (numbered relative to the transcription initiation site at +1) is capable of conferring cardiac specific expression to a "minimal" cTNT p...
متن کاملCCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter.
The cytochrome b heavy chain (gp91-phox) is expressed exclusively in terminally differentiating myelomonocytic cells. The human gp91-phox gene spans approximately 30 kilobases, and is divided into 13 exons. A ubiquitous factor that is indistinguishable from the CCAAT-binding factor CP1 interacts in vitro with the distal gp91-phox promoter CCAAT box motif. CP1 binding is prevented, however, by a...
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The inflammatory response is thought to play important roles in tissue healing. The hypothesis of this study was that the inflammatory cytokine, interferon (IFN)-, is produced endogenously following skeletal muscle injury and promotes efficient healing. We show that IFN-is expressed at both mRNA and protein levels in skeletal muscle following injury, and that the time course of IFN-expression c...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.14.8267