Characterization of Complement Factor H Binding to Yersinia enterocolitica Serotype O:3

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Characterization of complement factor H binding to Yersinia enterocolitica serotype O:3.

A number of bacteria bind factor H (FH), the negative regulator of the alternative complement pathway, to avoid complement-mediated killing. Here we show that a gram-negative enteric pathogen, Yersinia enterocolitica serotype O:3, uses two virulence-related outer membrane (OM) proteins to bind FH. With Y. enterocolitica O:3 mutant strains displaying different combinations of surface factors rel...

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ژورنال

عنوان ژورنال: Infection and Immunity

سال: 2008

ISSN: 0019-9567,1098-5522

DOI: 10.1128/iai.00313-08