Characterization of encapsulated porcine cardiosphere-derived cells embedded in 3D alginate matrices

Myocardial infarction is caused by an interruption of coronary blood flow, leading to one the main death causes worldwide. Current therapeutic approaches are palliative and not able solve loss cardiac tissue. Cardiosphere derived cells (CDCs) reduce scarring, increase viable myocardium, with safety adequate biodistribution, but show a low rate engraftment survival after implantation. In order retention, we propose encapsulation CDCs within three-dimensional alginate-poly-L-lysine-alginate matrix as therapy for regeneration. this work, demonstrate in alginate matrix, no decrease viability over month, showing preservation phenotype, differentiation potential, gene expression profile growth factor release encapsulation, moving step forward clinical translation regeneration heart failure.