Characterization of Low-Pathogenic H5 Subtype Influenza Viruses from Eurasia: Implications for the Origin of Highly Pathogenic H5N1 Viruses

Discrimination between Highly Pathogenic and Low Pathogenic H5 Avian Influenza A Viruses

700 Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 12, No. 4, April 2006 9. Monath TP, Caldwell JR, Mundt W, Fusco J, Johnson CS, Buller M, et al. ACAM2000 clonal Vero cell culture vaccinia virus (New York City Board of Health strain): a second-generation smallpox vaccine for biological defense. Int J Infect Dis. 2004;8S2: S31–44. 10. Graham BS, Belshe RB, Clements ML, Dolin R, Corey L, ...

Risk Assessment of the Introduction and Spread of Highly Pathogenic Avian Influenza Viruses (H5-Subtypes) Via Migratory Birds in Iran

Background and Objectives: HPAI has economic and public health importance. Aquatic and shore migratory birds are the main reservoirs and the cause of the spread of viruses across countries. The aim of study was risk assessment of the spread of the avian influenza H5 viruses.   Methods: In this qualitative study, structured interviews and focus group discussions were used to assess the risk of...

Novel Eurasian Highly Pathogenic Avian Influenza A H5 Viruses

[Vaccines against highly pathogenic influenza viruses of the avian origin].

Worldwide spreading of H5 and H7 highly pathogenic influenza viruses of the avian origin, which periodically infect and kill humans without prior adaptation, poses a constant threat of the new pandemic. The effectiveness of the pandemic prevention completely depends on the quality of the existing influenza vaccines. Typical methods of the vaccine production from the antigenically relevant strai...

Characterization of Neuraminidases from the Highly Pathogenic Avian H5N1 and 2009 Pandemic H1N1 Influenza A Viruses

To study the precise role of the neuraminidase (NA), and its stalk region in particular, in the assembly, release, and entry of influenza virus, we deleted the 20-aa stalk segment from 2009 pandemic H1N1 NA (09N1) and inserted this segment, now designated 09s60, into the stalk region of a highly pathogenic avian influenza (HPAI) virus H5N1 NA (AH N1). The biological characterization of these wi...