Characterization of new bone morphogenetic protein (Bmp)-2 regulatory alleles
نویسندگان
چکیده
منابع مشابه
Gremlin1 preferentially binds to bone morphogenetic protein-2 (BMP-2) and BMP-4 over BMP-7.
Gremlin (Grem1) is a member of the DAN family of secreted bone morphogenetic protein (BMP) antagonists. Bone morphogenetic protein-7 (BMP-7) mediates protective effects during renal fibrosis associated with diabetes and other renal diseases. The pathogenic mechanism of Grem1 during diabetic nephropathy (DN) has been suggested to be binding and inhibition of BMP-7. However, the precise interacti...
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The aim of the study was to investigate the effect of a sustained release of bone morphogenetic protein2 (BMP-2) incorporated in a polymeric implant coating on bone healing. In vitro analysis revealed a sustained, but incomplete BMP-2 release until Day 42. For the in vivo study, the rat tibia osteotomy was stabilized either with control or BMP-2 coated wires, and the healing progress was follow...
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PURPOSE Transferring the bone morphogenetic protein 2 (BMP-2) genes into the tissues or cells can improve the bone healing of the fracture has been widely accepted. We evaluated the efficiency of using gene gun to transfer the BMP-2 gene thereby affected the healing of a fractured bone. METHODS The vector coding for BMP-2 was constructed by a non-replicating encephalo-myocarditis virus (ECMV)...
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background: bone morphogenetic protein 2 (bmp- 2) belongs to the tgf-β superfamily of proteins and plays an important role in the development of bone and cartilage. bmp- 2 is also associated with maintenance and repair of damaged bone. recombinant human bone morphogenetic protein 2 (rhbmp- 2) is now produced by genetic engineering techniques and used in treatment of thin bone fractures in the j...
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The bone morphogenetic protein-2 (BMP-2) has been implicated in follicle growth and steroidogenic functions of the ovary. The BMP-2 belongs to the BMPs subfamily of TGF-β super family. The present study was carried out in sheep granulosa cell culture to study the effect of different doses of BMP-2 0ng/ml (control group), 30ng/ml, 50ng/ml and 100ng/ml on granulosa cell steriodogenic function. Fo...
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ژورنال
عنوان ژورنال: genesis
سال: 2017
ISSN: 1526-954X
DOI: 10.1002/dvg.23035