CHARACTERIZATION OF RESISTANCE TO BROMOBENZENE-INDUCED HEPATOTOXICITY BY MICROARRAY
نویسندگان
چکیده
منابع مشابه
Bromobenzene-induced hepatotoxicity at the transcriptome level.
Rats were exposed to three levels of bromobenzene, sampled at 6, 24, and 48 h, and liver gene expression profiles were determined to identify dose and time-related changes. Expression of many genes changed transiently, and dependent on the dose. Few changes were identified after 6 h, but many genes were differentially expressed after 24 h, while after 48 h, only the high dose elicited large eff...
متن کاملCurative effects of Cassia fistula fruit extract on bromobenzene-induced hepatotoxicity and nephrotoxicity in mice
Background & objectives: The present investigation was designed to evaluate the post-treatment properties of the hydroalcoholic fruit extract of cassia fistula (golden shower tree) in male Albino mice. Materials & Methods: Biomarkers and histological liver and kidney alterations, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (...
متن کاملCurative effects of Cassia fistula fruit extract on bromobenzene induced hepatotoxicity and nephrotoxicity in mice
Background & objectives: The present investigation was designed to evaluate the post-treatment properties of the hydroalcoholic fruit extract of cassia fistula (golden shower tree) in male Albino mice. Materials & Methods: Biomarkers and histological liver and kidney alterations, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), γ-glutamyl transferase...
متن کاملAmelioration of bromobenzene hepatotoxicity by Withania somnifera pretreatment: Role of mitochondrial oxidative stress
The present study investigated the possible protective role of Withania somnifera (Linn.) Dunal (Solanaceae) root powder against bromobenzene-induced oxidative damage in rat liver mitochondria. Administration of bromobenzene (10 mmol/kg body weight) to rats resulted in increased levels of liver marker enzymes, lipid peroxidation, TNF-α, IL-1β and VEGF. There was also marked depletion in the lev...
متن کاملHistopathological and Biomedical parameters Determination in the Protective Effect of Hydroalcoholic Extract of Allium Jesdianum on Hepatotoxicity Induced by Bromobenzene in Mice
Allium Jesdianum (AJ) is the native plant mostly grown in Middle East region that has the excellent pharmacological properties. In this study, we evaluated the hepatoprotective effect of hydroalcoholic extract of AJ on liver injury induced by Bromobenzene (BB) in male mice. Animals were randomly divided into five groups, control group received normal saline plus olive oil, groups 2-4 received(5...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 2007
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.32.129