Characterization of the herpes simplex virus type 2 (HSV-2) US2 gene product and a US2-deficient HSV-2 mutant.
نویسندگان
چکیده
منابع مشابه
Seroepidemiological Study of Herpes Simplex Virus Type 2 (HSV-2) Antibody in Shiraz, Iran
Background: Herpes Simplex Virus (HSV) Type 2 is a widespread human infectious agent responsible for persistent and latent infections. Objectives: To estimate the regional seroprevalence of anti HSV-2 antibody in Shiraz, Iran and to investigate the possible correlation of seropositivity with malignant changes in subjects’ Papanicolaou (Pap) tests. Methods: Data were collected in a cross-section...
متن کاملThe Us2 gene product of herpes simplex virus 2 is a membrane-associated ubiquitin-interacting protein.
The Us2 gene encodes a tegument protein that is conserved in most members of the Alphaherpesvirinae. Previous studies on the pseudorabies virus (PRV) Us2 ortholog indicated that it is prenylated, associates with membranes, and spatially regulates the enzymatic activity of the MAP (mitogen-activated protein) kinase ERK (extracellular signal-related kinase) through direct binding and sequestratio...
متن کاملNo Role of Herpes Simplex Virus Type 2 (HSV-2) Infection on HIV Progression in Naïve HIV Patients
Background: Herpes simplex virus type 2 (HSV-2) is a common infection in human immunodeficiency virus (HIV) patients and may accelerate HIV progression by rising HIV viral load and decreasing CD4 count. However, the available data regarding the influence of HSV-2 seropositivity on HIV progression in HIV individuals are inconclusive. Therefore, we aimed to determine HSV-2 seroprevalence in na&iu...
متن کاملMutational analysis of the virion host shutoff gene (UL41) of herpes simplex virus (HSV): characterization of HSV type 1 (HSV-1)/HSV-2 chimeras.
During lytic herpes simplex virus (HSV) infections, the half-lives of host and viral mRNAs are regulated by the HSV virion host shutoff (Vhs) protein (UL41). The sequences of the UL41 polypeptides of HSV type 1 (HSV-1) strain KOS and HSV-2 strain 333 are 87% identical. In spite of this similarity, HSV-2 strains generally shut off the host more rapidly and completely than HSV-1 strains. To exami...
متن کاملseroepidemiological study of herpes simplex virus type 2 (hsv-2) antibody in shiraz, iran
background: herpes simplex virus (hsv) type 2 is a widespread human infectious agent responsible for persistent and latent infections. objectives: to estimate the regional seroprevalence of anti hsv-2 antibody in shiraz, iran and to investigate the possible correlation of seropositivity with malignant changes in subjects’ papanicolaou (pap) tests. methods: data were collected in a cross-section...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 1998
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-79-11-2777