Characterization of Toll-like receptors in the female reproductive tract in humans


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Characterization of Toll-like receptors in the female reproductive tract in humans.

BACKGROUND Rapid innate immune defences against infection involve the recognition of invading pathogens by specific pattern recognition receptors recently attributed to the family of Toll-like receptors (TLR). Little is known about the in vivo protein expression or distribution of TLR in the female reproductive tract in humans. It is likely that TLR distribution in the female reproductive tract...

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Background: Male infertility refers to the inability of a male to achieve a pregnancy in a fertile female. The root of many causes of infertility is miscommunication between immune and reproductive system. Male reproductive system is very sensitive and vulnerable, infections can hinder maturation and movement of spermatozoa lead to impaired fertility.All species need an immediate reply to the m...

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Toll-Like Receptors in the Cycling Female Reproductive Tract and During Pregnancy

For many years it was thought that the female reproductive tract was a sterile environment, devoid of immune cells or pathogens. We now know that the immune system represents an important component of reproductive tissues, influencing many of its biological functions. Similarly, bacteria are present within the female reproductive tract as a normal component. Therefore, the female reproductive t...

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Background: In the past decade, childlessness has become a most important problem in the world. At the same time evidence confirms a link between sexually transmitted diseases (STDs) and infertility problem. Some of viral STDs are: HIV, HPV, HSVand so on. The innate immune system is essential for the initial detection of invading viruses and subsequent activation of adaptive immunity. also, The...

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عنوان ژورنال: Human Reproduction

سال: 2005

ISSN: 1460-2350,0268-1161

DOI: 10.1093/humrep/deh775