Chinks in the Armor? Filaggrin-Depleted Skin Could Increase Environmental Exposures
نویسندگان
چکیده
منابع مشابه
Chinks in the Armor? Filaggrin-Depleted Skin Could Increase Environmental Exposures
“This idea that a certain level of exposure to a chemical can mean something very different depending on your genetic makeup is quite new and important,” says Shanna Swan, a reproductive health scientist at the Mount Sinai School of Medicine in New York, who was not involved in the study. Small percentages of Europeans and Asians have a genetic mutation that diminishes the production of filaggr...
متن کاملLooking for Chinks in the Armor of Bacterial Biofilms
D avid Davies stood at the hospital bedside of his great-aunt, who had recently had all her toes amputated to try to prevent persistent wounds from spreading. It didn't work; doctors would later amputate both of her feet, and she never returned to her independent life. As Davies thinks back to this episode from his high-school days, " I remember wondering 'How come, in this era of antibiotics, ...
متن کاملChinks in the Armor of Public Key Cryptosystems
Potential weaknesses in public key cryptosystem design and use are identiied with emphasis on a particular vulnerability resulting from the encryption of ordinary natural language plaintext. This weakness occurs when an insuuciently long block length is used to encrypt low entropy natural language and ordinary numeric plaintext rendered in 8-bit character sets such as ASCII or EBCDIC. A compute...
متن کاملFilaggrin mutations and the skin.
Filaggrin is very important in the terminal differentiation of the skin and the formation of cornified envelope in the stratum corneum. Several mutations in the filaggrin gene have been identified in the last decade, mostly from the European countries. Loss of function mutations in the filaggrin gene results in reduced production of filaggrin, depending on the type and site of mutation. Such mu...
متن کاملSkin barrier in atopic dermatitis: beyond filaggrin*
Atopic dermatitis is a chronic inflammatory skin disease with a complex pathogenesis, where changes in skin barrier and imbalance of the immune system are relevant factors. The skin forms a mechanic and immune barrier, regulating water loss from the internal to the external environment, and protecting the individual from external aggressions, such as microorganisms, ultraviolet radiation and ph...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2014
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.122-a108