Chip-Based and Wearable Tools for Isothermal Amplification and Electrochemical Analysis of Nucleic Acids

The determination of nucleic acids has become an analytical diagnostic method with many applications in fields such as biomedical sciences, environmental monitoring, forensic identification, and food safety. Among the different methods for acid analysis, those based on polymerase chain reaction (PCR) are nowadays considered gold standards. Isothermal amplification interesting alternative, especially design chip-based architectures. Biosensing platforms hold great promise simple rapid detection since they can be embedded lab-on-a-chip tools to perform extraction, amplification, steps. Electrochemical transduction schemes particularly small portable devices due miniaturization, low-energy consumption, multianalyte capability. aim this review is summarize isothermal combined electrochemical biosensing techniques development wearable sensors. Different revised, examples discussed. Finally, a discussion patented also included.