Chiral Separation of Deprenyl-N-Oxide Isomers by Capillary Electrophoresis Using Various Cyclodextrin Derivatives
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چکیده
منابع مشابه
Chiral separation of deprenyl-N-oxide isomers by capillary electrophoresis using various cyclodextrin derivatives.
Chiral separation of deprenyl-N-oxide isomers is presented using capillary electrophoresis in the presence of various cyclodextrin (CD) derivatives. This recently identified metabolite of R-(-)-deprenyl may possess desirable pharmacological activities. The effect of the cavity size and the substituents of the CD are examined on the enantiomer resolution of the compound having an asymmetric cent...
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It is widely recognized today that chirality is an important modulator of the effects and properties of chiral substances in a variety of fields such as pharmacology, agrochemistry, food chemistry, environmental chemistry, etc. The phenomenon of chirality exists in all biological systems. Therefore, analytical methods for the determination of single enantiomers in different natural and industri...
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Carvedilol is administered as a racemic mixture of the R(+)- and S(-)-enantiomers, although it was demonstrated that the two enantiomers exhibit different pharmacological effects and stereoselective pharmacokinetics. The aim of this study was the evaluation of several native and derivatized cyclodextrines as chiral selectors for the separation of carvedilol enantiomers. Stereoselective interact...
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Due to high resolution power of sulfated cyclodextrins (HS-CDs), utilization of these selectors for chiral resolution of 7 basic and 2 zwitterionic drugs have been examined. Experiments were performed on a HP3DCE instrument equipped with an on-column diode array UV absorbance detector. Fused silica capillaries with an inner diameter of 50 ?m, an outer diameter of 365 ?m, and a total length of 4...
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ژورنال
عنوان ژورنال: Journal of Chromatographic Science
سال: 2004
ISSN: 0021-9665,1945-239X
DOI: 10.1093/chromsci/42.1.21