Chromatin density and splicing destiny: on the cross-talk between chromatin structure and splicing
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چکیده
منابع مشابه
Chromatin density and splicing destiny: on the cross-talk between chromatin structure and splicing.
How are short exonic sequences recognized within the vast intronic oceans in which they reside? Despite decades of research, this remains one of the most fundamental, yet enigmatic, questions in the field of pre-mRNA splicing research. For many years, studies aiming to shed light on this process were focused at the RNA level, characterizing the manner by which splicing factors and auxiliary pro...
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The complex processes of mRNA transcription and splicing were traditionally studied in isolation. In vitro studies showed that splicing could occur independently of transcription and the perceived wisdom was that, to a large extent, it probably did. However, there is now abundant evidence for functional interactions between transcription and splicing, with important consequences for splicing re...
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Myh1 is a DNA glycosylase that is involved in base excision repair after oxidation damage. It excises mis-incorporated adenine opposite to the lesion 8-oxoG. The human homolog MUTYH, is important in tumour development as mutations in the MUTYH lead to G: C to T: A transversion mutations in MUTYH hereditary colon cancer. Pst2 (Sin3 homolog) is a scaffold protein and forms a complex with Clr6 His...
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Much remains unknown concerning the mechanism by which the splicing machinery pinpoints short exons within intronic sequences and how splicing factors are directed to their pre-mRNA targets. One probable explanation lies in differences in chromatin organization between exons and introns. Proteomic, co-immunoprecipitation, and sedimentation analyses described here indicate that SF3B1, an essenti...
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Nature has devised sophisticated cellular machinery to process mRNA transcripts produced by RNA Polymerase II, removing intronic regions and connecting exons together, to produce mature RNAs. This process, known as splicing, is very closely linked to transcription. Alternative splicing, or the ability to produce different combinations of exons that are spliced together from the same genomic tem...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2010
ISSN: 0261-4189,1460-2075
DOI: 10.1038/emboj.2010.71