Chromosome aberrations in atypical chronic lymphocytic leukemia: a cytogenetic and interphase cytogenetic study
نویسندگان
چکیده
منابع مشابه
Trisomy 12 in chronic lymphocytic leukemia: an interphase cytogenetic study.
Interphase cytogenetics by means of in situ hybridization with the chromosome 12-specific biotinylated alpha satellite DNA probe pSP 12-1 was used for the study of trisomy 12, the most common chromosomal abnormality in chronic lymphocytic leukemia. In situ hybridization was performed on methanol/acetic acid fixed cells of conventional cytogenetic preparations from eight patients and on morpholo...
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In the 90’s, only approximately 50% of chronic lymphocytic leukemia (CLL) could be shown to carry a chromosome defect, a figure reflecting inadequate cell division. The introduction of FISH allowed for the detection of chromosome aberrations in 80% of the cases and every patient could be included in a specific group according to a hierarchical cytogenetic classification as follows: 17p> 11q> +1...
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Select cytogenetic abnormalities such as del(17)(p13.1) and del(11)(q22-q23)predict rapid disease progression and inferior survival in chronic lymphocytic leukemia (CLL). We sought to determine the impact of the four most common interphase cytogenetic abnormalities in 28 CLL patients relative to response to three-times-a-week rituximab therapy. Abnormalities were noted in 25 of the 28 patients ...
متن کاملCytogenetic Abnormalities with Interphase FISH Method and Clinical Manifestation in Chronic Lymphocytic Leukemia Patients in North-East of Iran
Background: Chronic lymphocytic leukemia (CLL) is one of the most prevalent adult leukemias. This malignancy is known by lymphocytosis for a duration of more than 3 months. In fact, it is a heterogeneous clinical disease with changeable progression. Chromosomal aberrations are significant parameters to predict result and survival rate and find treatment strategies for each patient. Cytogenetic ...
متن کاملCorrelative Interphase Cytogenetic Analysis
Background: A patient with multiple myeloma developed myelodysplastic syndrome (MDS). Chromosomal analysis performed after the development of MDS revealed monosomy of chromosome 9 in all the meta-phases. We wished to identify the extent of the clone with the chromosomal abnormality originating from MDS clone. Methods: A correlative interphase study by fluorescence in situ hybridization (FISH) w...
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ژورنال
عنوان ژورنال: Leukemia
سال: 1997
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2400818