Chronic Cyclooxygenase-2 Inhibition Promotes Myofibroblast-Associated Intestinal Fibrosis
نویسندگان
چکیده
منابع مشابه
Chronic cyclooxygenase-2 inhibition promotes myofibroblast-associated intestinal fibrosis.
Anti-inflammatory drugs prevent intestinal tumor formation, an activity related to their ability to inhibit inflammatory pathway signaling in the target tissue. We previously showed that treatment of Min/(+) mice with the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib induced rapid tumor regression; however, drug-resistant tumors appeared with long-term treatment. In this study, we inve...
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Membrane arachidonic acid is converted by cyclooxygenase (COX) into prostaglandin (PG) G(2) and then to PGH(2) which is subsequently metabolized to PGE(2) by PGE synthase (PGES). Both COX-1 and COX-2 play critical roles in intestinal polyp formation, whereas COX-2 is also expressed in cancers of a variety of organs. Likewise, inducible microsomal PGES (mPGES-1) is expressed in several types of ...
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Indoleamine 2,3-dioxygenase 1 (IDO1) metabolizes L-tryptophan to kynurenines (KYN), inducing T-cell suppression either directly or by altering antigen-presenting-cell function. Cyclooxygenase (COX)-2, the rate-limiting enzyme in the synthesis of prostaglandins, is over-expressed by several tumours. We aimed at determining whether COX-2 inhibitors down-regulate the IFN--induced expression of ID...
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ژورنال
عنوان ژورنال: Cancer Prevention Research
سال: 2010
ISSN: 1940-6207,1940-6215
DOI: 10.1158/1940-6207.capr-09-0146