Chronic inflammation: a failure of resolution?

REV IEW ART ICLE Chronic inflammation: a failure of resolution?

Acute inflammation is characterized by leucocyte recruitment from the circulation, classically defined by the initial trafficking of polymorphonuclear granulocytes followed by monocytes which differentiate locally into macrophages (Majno 1975). Invariably, this response is triggered by tissue mast cells and resident macrophages, whose degranulation and activation sequentially release a battery ...

Chronic Heart Failure and Inflammation

Heart failure (HF) is primarily a clinical diagnosis that develops secondary to either left ventricular (LV) systolic and diastolic dysfunctions. Despite significant advancements in medical therapies designed to both prevent HF development and treat HF once established, the prognosis of patients after their first hospital admission is poor. Worldwide, 2% to 17% of patients die during their firs...

Chronic Low-grade Inflammation after Exercise: Controversies

[Inflammation and endothelial dysfunction in patients with chronic heart failure].

BACKGROUND In chronic heart failure (CHF), endothelial dysfunction (ED) is a consequence of an imbalance of vascular tone regulating substances. The relationship between ED and inflammation has not been fully investigated. AIM To assess the association between inflammation and ED in CHF. MATERIAL AND METHODS Forty two patients aged 56+/-14 years (80% male) with a CHF in functional capacity ...

Salt Intake Is Associated with Inflammation in Chronic Heart Failure

BACKGROUND Chronic Heart Failure (CHF) is highly prevalent and is associated with high morbidity and mortality rates. It has been well established that excessive intake of sodium chloride (salt) induced hypertension in some populations. Although salt seems to induce cardiovascular diseases through elevation of blood pressure, it has also been indicated that salt can induce cardiovascular diseas...