Chronic nicotinic exposure decreases the synaptic strength of nAChR‐mediated glutamatergic input onto neonatal hypoglossal motoneurons
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چکیده
منابع مشابه
Nicotinic excitation of rat hypoglossal motoneurons.
Hypoglossal motoneurons (HMNs), which innervate the tongue muscles, are involved in several important physiological functions, including the maintenance of upper airway patency. The neural mechanisms that affect HMN excitability are therefore important determinants of effective breathing. Obstructive sleep apnea is a disorder characterized by recurrent collapse of the upper airway that is likel...
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We investigated whether capsaicin modulated synaptic transmission to hypoglossal motor neurons (HMNs) by acting on transient receptor potential vanilloid type 1 (TRPV1) receptors. Using whole-cell patch clamp recording from neonatal rat HMNs, we found that capsaicin increased spontaneous excitatory post-synaptic current (sEPSC) frequency and amplitude. Interestingly, the only effect of capsaici...
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The release of vasopressin and oxytocin from the supraoptic nucleus (SON) neurons is tonically regulated by excitatory glutamatergic and inhibitory GABAergic synaptic inputs. Acetylcholine is known to excite SON neurons and to elicit vasopressin release. Cholinergic receptors are located pre- and postsynaptically in the SON, but their functional significance in the regulation of SON neurons is ...
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1 COMMON SYNAPTIC INPUT TO THE HUMAN HYPOGLOSSAL MOTOR 2 NUCLEUS. 3 4 Christopher M. Laine and E. Fiona Bailey 5 6 7 Affiliation: Department of Physiology, 8 College of Medicine, 9 The University of Arizona 10 Tucson, Arizona, 11 U.S.A. 85721-0093 12 13 Correspondence to: E. Fiona Bailey Ph.D., 14 Department of Physiology 15 College of Medicine 16 The University of Arizona 17 Tucson, AZ 85721-0...
متن کاملDevelopmental nicotine exposure alters neurotransmission and excitability in hypoglossal motoneurons.
Hypoglossal motoneurons (XII MNs) control muscles of the mammalian tongue and are rhythmically active during breathing. Acetylcholine (ACh) modulates XII MN activity by promoting the release of glutamate from neurons that express nicotinic ACh receptors (nAChRs). Chronic nicotine exposure alters nAChRs on neurons throughout the brain, including brain stem respiratory neurons. Here we test the h...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.1064.2