Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation
نویسندگان
چکیده
منابع مشابه
Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation.
Intraflagellar transport proteins (IFT) are required for hedgehog (Hh) signalling transduction that is essential for bone development, however, how IFT proteins regulate Hh signalling in osteoblasts (OBs) remains unclear. Here we show that deletion of ciliary IFT80 in OB precursor cells (OPC) in mice results in growth retardation and markedly decreased bone mass with impaired OB differentiation...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2016
ISSN: 2041-1723
DOI: 10.1038/ncomms11024