Ciliary neurotrophic factor analogue aggravates CCl4-induced acute hepatic injury in rats
نویسندگان
چکیده
منابع مشابه
Red wine ameliorates CCl4 – induced acute liver injury in rats
Consumption of a naturally occurring polyphenol, in moderate amounts, has been suggested to be beneficial to health. The present study investigated the efficacy of red wine on prevention of carbon tetrachloride (CCl4) induced acute hepatic injury in wistar rats. Hepatic damage due to CCl4 intoxication was assessed by employing biochemical parameters, markers of hepatic oxidative damage were mea...
متن کاملCiliary neurotrophic factor: pharmacokinetics and acute-phase response in rat.
Ciliary neurotrophic factor (CNTF) supports the survival of motoneurons in vitro and in vivo. Recombinant CNTF is an investigational drug for the treatment of amyotrophic lateral sclerosis. We determined the pharmacokinetics of radioiodinated CNTF after intravenous injection into rats. CNTF shows a biphasic clearance with an initial plasma half-life of 2.9 minutes and is removed from the circul...
متن کاملHepatoprotective Activity of Cucumis trigonus Roxb. Fruit Against CCl4 Induced Hepatic Damage in Rats
In India, a number of medicinal plants and their formulations are used to cure hepatic disorders in traditional systems of medicine. No systemic study has been done on protective effect of Cucumis trigonus Roxb. (Cucurbitaceae) to treat hepatic diseases. Protective action of C. trigonus fruit extracts was evaluated in this study in animal model of hepatotoxicity, which was induced by carbon tet...
متن کاملAltered pharmacokinetics of daunorubicin in rats with CCl4-induced hepatic injury.
PURPOSE The effect of CCl4-induced experimental hepatic injury (CCl4-EHI) on the pharmacokinetics of daunorubicin was investigated systemically in rats, in an attempt to elucidate the major determinants of the effect of CCl4-EHI on the pharmacokinetics of the drug. METHODS CCl4-EHI was induced in rats by a single intraperitoneal injection of CCl4 (1 mL/kg rat), and a 24 h fasting period. Daun...
متن کاملTherapeutic efficacy of Nigella sativa Linn. seed extract against CCl4 induced hepatic injury in Wistar rats.
Carbon tetrachloride (CCl4) intake damages liver. We evaluated therapeutic potential of aqueous extract of Nigella sativa seeds against CCl4 induced liver damage in rats. The hepatic damage induced by CCl4 @ 1.5 mL/kg, ip was evidenced by a significant increase in the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, protein and urea lipid peroxidation (LPO) as we...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Canadian Journal of Physiology and Pharmacology
سال: 2017
ISSN: 0008-4212,1205-7541
DOI: 10.1139/cjpp-2016-0564