Ciliary Neurotrophic Factor Receptor α in Spinal Motoneurons is Regulated by Gonadal Hormones
نویسندگان
چکیده
منابع مشابه
Ciliary neurotrophic factor receptor alpha in spinal motoneurons is regulated by gonadal hormones.
Ciliary neurotrophic factor receptor alpha (CNTFRalpha) is the ligand-binding component of the CNTF receptor. CNTFRalpha expression is essential for the normal development of spinal motoneurons and is required for the development of a sex difference in motoneuron number in androgen-sensitive perineal motoneurons. We used immunocytochemistry to examine the expression and hormone regulation of CN...
متن کاملEndogenous ciliary neurotrophic factor is a lesion factor for axotomized motoneurons in adult mice.
Ciliary neurotrophic factor (CNTF) is an abundant cytosolic molecule in myelinating Schwann cells of adult rodents. In newborn animals in which CNTF is not yet expressed, exogenous CNTF that is locally administered very effectively protects motoneurons from degeneration by axotomy. To evaluate whether endogenous CNTF, released after nerve injury from the cytosol of Schwann cells, supports moton...
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Ciliary neurotrophic factor (CNTF) has potent survival-promoting effects on motoneurons in vitro and in vivo. We examined knockout mice with null mutations of the gene for either CNTF itself or the alpha-subunit of the CNTF receptor (CNTFRalpha) to assess whether CNTF and/or its receptors are involved in the development of a sexually dimorphic neuromuscular system. Male rodents have many more m...
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متن کاملCloning, Mapping, and Retinal Expression of the Canine Ciliary Neurotrophic Factor Receptor α (CNTFRα)
METHODS. The complete coding sequence of the canine CNTFR cDNA was cloned, and radiation hybrid (RH) mapping was used to determine the chromosomal localization of the gene. CNTFR mRNA expression in retina and other tissues was examined by reverse transcription–polymerase chain reaction. The cellular distribution of CNTFR in the canine retina was studied by in situ hybridization and immunocytoch...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1998
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.18-21-08720.1998