Citral effect in male NMRI mice nonalcoholic steatosis model: assessing biochemical and histological parameters and PPARα gene expression
نویسندگان
چکیده
منابع مشابه
The effect of Nitrochalcone on biochemical indicators and PPAR-α gene expression in nonalcoholic male NMRI mice steatosis model
Introduction: Non-alcoholic fatty liver disease (NAFLD) is associated with oxidative stress, inflammation, and decrease in peroxisome proliferator-activated receptor alpha (PPAR-α) expression. Nitrochalcone is effective ingredient of chalcones with anti-inflammatory, anti-cancer and anti-hyperglycemic properties. This study examined the effect of intraperitoneal (IP) administration of nitrochal...
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MicroRNA-34a (miR-34a) is thought to be involved in nonalcoholic fatty liver disease (NAFLD). However, the association between altered expression of miR-34a and the pathophysiological features of NAFLD remains unclear. Here, we investigated the mechanisms by which miR-34a influences NAFLD through the PPARα-related pathway. Real-time quantitative PCR, western blotting and other assays kit were u...
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15 صفحه اولEffect of treadmill exercise on catalepsy and the expression of the BDNF gene in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine male NMRI mice
Objective(s): It is known that treadmill exercise has beneficial effects on the nervous system. The brain-derived neurotrophic factor (BDNF) plays a role in such effects. This study aimed at investigating effects of intermittent treadmill exercise-induced behavioral, histology, and immunohistochemistry (H&E;, TH) measurement of brain interleukin-10 (IL-10) in a mice m...
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ژورنال
عنوان ژورنال: Brazilian Journal of Pharmaceutical Sciences
سال: 2018
ISSN: 2175-9790
DOI: 10.1590/s2175-97902018000317596