Classical and molecular methods in differentiation of mantle cell lymphoma and small lymphocytic lymphoma in composite lymphoma: a case report
نویسندگان
چکیده
Composite lymphoma (CL) is a very rare phenomenon. To date, only few cases of composite mantle cell (MCL) and chronic lymphocytic leukemia (CLL) or small (SLL) have been reported by Sun et al. (Cytometry B Clin Cytom 2018;94(1):148-50), Hoeller (Hum Pathol 2013;44(1):110-21), Papathomas 2012;43(4):467-80). In the majority CL cases, clonality relationship was not examined could be proven. So far, there no optimal treatment strategy for CL. However, it has commonly accepted rule that more aggressive component should treated first. Thus, vital importance to precisely distinguish components determine response particular treatment. This may done monitoring molecular minimal residual disease (mMRD) as Pott (Blood 2010;115(16):3215-23) (Semin Hematol 2011;48(3):172-84). report presents possibility determining each using flow cytometry in parallel with specific markers. Molecular analysis performed quantitative real-time PCR (qPCR) two markers: IGH rearrangement van Dongen (Leukemia 2003;17(12):2257-317) SOX11 expression Hamborg (Eur J Haematol 2012;89(5):385-94) Szostakowska (Med Oncol 2018;35(4):49). The allowed us MCL SLL subclones 60-year-old male multifocal MCL/SLL this marker detected Swerdlow (2001) Mozos (Haematologica 2009;94(11):1555-62). our best knowledge, first example use mMRD components.
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ژورنال
عنوان ژورنال: Journal of Hematopathology
سال: 2021
ISSN: ['1865-5785', '1868-9256']
DOI: https://doi.org/10.1007/s12308-020-00426-4