Clathrin Heavy Chain Knockdown Impacts CXCR4 Signaling and Post-translational Modification
نویسندگان
چکیده
منابع مشابه
Allosteric post-translational modification codes.
Post-translational modifications (PTMs) have been recognized to impact protein function in two ways: (i) orthosterically, via direct recognition by protein domains or through interference with binding; and (ii) allosterically, via conformational changes induced at the functional sites. Because different chemical types of PTMs elicit different structural alterations, the effects of combinatorial...
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Post-translational modifications (PTMs) are chemical alterations to a protein following translation, regulating stability and function. Reversible phosphorylation is an example of an important and well studied PTM involved in a number of cellular processes. SUMOylation is another PTM known to modify a large number of proteins and plays a role in various cellular processes including: cell cycle ...
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A new global post-translational modification (PTM) discovery strategy, G-PTM-D, is described. A proteomics database containing UniProt-curated PTM information is supplemented with potential new modification types and sites discovered from a first-round search of mass spectrometry data with ultrawide precursor mass tolerance. A second-round search employing the supplemented database conducted wi...
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We have deduced the 1675-amino acid sequence of rat clathrin heavy chain from cDNA clones and predict a protein of Mr 191,569. We have established the polarity of the heavy chain and assigned sequence positions to several structural landmarks of the clathrin leg. The terminal domain at the distal end of the clathrin leg is at the amino terminus of the heavy chain. It is connected to the distal ...
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Post-translational modifications of proteins control many biological processes. This is also an important process in the pathogenesis of diabetes mellitus. Adiponectin is an insulin-sensitizing adipokine with antidiabetic, anti-atherogenic, anti-inflammatory and cardioprotective properties. The role of posttranslational modifications in regulating the biosynthesis of high molecular weight adipo...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2019
ISSN: 2296-634X
DOI: 10.3389/fcell.2019.00077