Clinical and dosimetric consequences of imperfect applicator insertion in cervical cancer brachytherapy

Dosimetric impacts of applicator displacements and applicator reconstruction-uncertainties on 3D image-guided brachytherapy for cervical cancer

PURPOSE To quantify the dosimetric impact of applicator displacements and applicator reconstruction-uncertainties through simulated planning studies of virtual applicator shifts. MATERIAL AND METHODS Twenty randomly selected high-dose-rate (HDR) titanium tandem-and-ovoid (T&O) plans were retrospectively studied. MRI-guided, conformal brachytherapy (MRIG-CBT) plans were retrospectively generat...

Virtual modelling of novel applicator prototypes for cervical cancer brachytherapy

BACKGROUND Standard applicators for cervical cancer Brachytherapy (BT) do not always achieve acceptable balance between target volume and normal tissue irradiation. We aimed to develop an innovative method of Target-volume Density Mapping (TDM) for modelling of novel applicator prototypes with optimal coverage characteristics. Patients and methods. Development of Contour-Analysis Tool 2 (CAT-2)...

Dosimetric Consequences of Uncertainties in High-Risk CTV (HR CTV) Delineation for Cervical Cancer Brachytherapy

Dosimetric evaluation of multilumen intracavitary balloon applicator rotation in high‐dose‐rate brachytherapy for breast cancer

The objective of this work is to evaluate dosimetric impact of multilumen balloon applicator rotation in high-dose-rate (HDR) brachytherapy for breast cancer. Highly asymmetrical dose distribution was generated for patients A and B, depending upon applicator proximity to skin and rib. Both skin and rib spacing was ≤ 0.7 cm for A; only rib spacing was ≤ 0.7 cm for B. Thirty-five rotation scenari...

Applicator reconstruction in MRI 3D image-based dose planning of brachytherapy for cervical cancer.

BACKGROUND AND PURPOSE To elaborate a method for applicator reconstruction for MRI-based brachytherapy for cervical cancer. MATERIALS AND METHODS Custom-made plastic catheters with a copper sulphate solution were made for insertion in the source channels of MR-CT compatible applicators: plastic and titanium tandem ring applicators, and titanium needles. The applicators were CT and MR scanned ...