Clinical and microbiological profile of persistent coagulase-negative staphylococcal bacteraemia in neonates
نویسندگان
چکیده
منابع مشابه
Use of rifampin in persistent coagulase negative staphylococcal bacteremia in neonates
BACKGROUND Coagulase negative staphylococci (CoNS) are the most common cause of neonatal sepsis in the Neonatal Intensive Care Unit (NICU). A minority of neonates does not respond to vancomycin therapy and develops persistent bacteremia, which may be treated with rifampin. We evaluated the use of rifampin in persistent CoNS bacteremia. METHODS Retrospective study of 137 neonates with CoNS bac...
متن کاملCoagulase-negative staphylococci: clinical, microbiological and molecular features to predict true bacteraemia.
Coagulase-negative staphylococci (CNS) are frequently isolated from blood cultures, where they may be only a contaminant or the cause of bacteraemia. Determining whether an isolate of CNS represents a true CNS bacteraemia is difficult, and there is no single criterion with sufficient specificity. The aim of this study was to assess those clinical, microbiological, pathogenic and genotypic featu...
متن کاملBlood culture volume and detection of coagulase negative staphylococcal septicaemia in neonates.
A prospective, blind study was carried out to determine: the amount of blood submitted for culture from neonates; whether small blood volumes resulted in false negative results; and whether there was a temporal relation between volume of blood cultured and time to positivity. Seventy three bottles were evaluated. They contained a median of 0.63 ml of blood. Twenty nine bottles (39.7%) contained...
متن کامل[Clinical significance of coagulase-negative staphylococci isolated from neonates].
OBJECTIVE To evaluate the clinical significance of coagulase-negative staphylococci (CNS) isolated from newborns' infections at Neonatal Unit of Hospital das Clínicas da Faculdade de Medicina de Botucatu. METHODS The CNS strains isolated were identified and classified as clinically significant and contaminant, based on a series of clinical and laboratory data obtained from patients who stayed...
متن کاملCoagulase negative staphylococcal sepsis in neonates: do we need to adapt vancomycin dose or target?
BACKGROUND Despite differences in types of infection and causative organisms, pharmacokinetic-pharmacodynamic (PKPD) targets of vancomycin therapy derived from adult studies are suggested for neonates. We aimed to identify doses needed for the attainment of AUC/MIC > 400 and AUC/MIC > 300 in neonates with sepsis and correlate these targets with recommended doses and treatment outcome. METHODS...
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ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 2011
ISSN: 1198-743X
DOI: 10.1111/j.1469-0691.2011.03489.x