Clinical Demonstrations of Controlled-Release Tablets Constructed by the Combined Usage of Shellac and Hydroxypropyl Methylcellulose

A new tablet system was examined for an intestinal delivery using hydroxypropyl methylcellulose (HPMC) and shellac. HPMC incorporated into the inside of tablet, shellac coated on surface, which evaluated its controlled-release property through several dissolution tests, firstly in vitro then via two kinds clinical studies with healthy volunteers. The were originally designed by employing X-ray photography movements tablets gastrointestinal tract electronical device to easily analyze absorption profile glucose, a model compound. It found that strongly suppressed simulated gastric fluid (pH 1.2) subsequently started disintegrate 6.8). first human study revealed could pass stomach without disintegrating. controlled release further confirmed analyses AUC, Cmax, Tmax blood glucose concentration other AUC Cmax significantly reduced our system, thus concluding combined addition coating unequivocally leads tract.