Clinical features and outcomes of combined hepatocellular carcinoma and cholangiocarcinoma versus hepatocellular carcinoma versus cholangiocarcinoma after surgical resection: a propensity score matching analysis

Abstract Background Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) is an infrequent type of primary liver cancer that comprises (HCC) (CC). This study investigated the clinicopathological features prognosis among cHCC-CC, HCC, CC groups. Methods We prospectively collected data 608 patients who underwent surgical resection for between 2011 2018 at E-Da Hospital, I-Shou University, Kaohsiung, Taiwan. Overall, 505 with were included, their features, overall survival (OS), recurrence recorded. OS rates analyzed using Kaplan–Meier analysis. Results In entire cohort, median age was 61 years 80% men. Thirty-five (7.0%) had 419 (82.9%) 51 (10.1%) CC. The cHCC-CC group more identical to those HCC than group. significantly lower in but not higher groups 50.1 months [95% confidence interval (CI): 38.7–61.2], 62.3 (CI: 42.1–72.9), 36.2 15.4–56.5), respectively. Cumulative 1, 3, 5 88.5%, 62.2%, 44.0%; 91.2%, 76.1%, 68.0%; 72.0%, 48.1%, 34.5%, After propensity score matching (PSM), different from or However, before after PSM. Furthermore, disease-free Conclusion rate PSM,