Clinical Features of Visual Disturbances in Leiden Thrombophilia

The Leiden Thrombophilia Study (LETS).

Our study grew from an attempt to solve a controversy. In 1987 protein C antigen level was assessed in a large cohort of healthy blood donors (1). Subjects in this cohort who were heterozygous for protein C deficiency did not suffer from venous thromboembolism. Family studies in four of the protein C deficient individuals showed autosomal inheritance of the defect. These findings seemed in cont...

Factor V Leiden Mutation Causing Thrombophilia

It has autosomal dominant inheritance and is the most common cause of inherited thrombophilia. FVL is the most prevalent thrombotic risk factor known in the Caucasian population (around 5%). [1] Heterozygotes have a three to five times increased risk of thrombosis. Homozygotes are much less common but have a much higher thrombotic risk, around eight times increased risk. It leads to a hypercoag...

Factor V Leiden Mutation Causing Thrombophilia

It has autosomal dominant inheritance and is the most common cause of inherited thrombophilia. FVL is the most prevalent thrombotic risk factor known in the Caucasian population (around 5%). [1] Heterozygotes have a three to five times increased risk of thrombosis. Homozygotes are much less common but have a much higher thrombotic risk, around eight times increased risk. It leads to a hypercoag...

Factor V Leiden in young patients with thrombophilia.

Clinical features of visual disturbances secondary to isolated sphenoid sinus inflammatory diseases

BACKGROUND Visual disturbances associated with isolated sphenoid sinus inflammatory diseases (ISSIDs) are easily misdiagnosed due to the nonspecific symptoms and undetectable anatomical location. The main objective of this retrospective case series is to investigate the clinical features of visual disturbances secondary to ISSIDs. METHODS Clinical data of 23 patients with unilateral or bilate...