Clinical, Morphologic, Immunophenotypic, and Molecular Cytogenetic Assessment of CD4–/CD8– γδ T-Cell Large Granular Lymphocytic Leukemia
نویسندگان
چکیده
منابع مشابه
Large granular lymphocytic leukemia: molecular pathogenesis, clinical manifestations, and treatment.
Large granular lymphocyte (LGL) leukemia represents a spectrum of rare lymphoproliferative diseases defined by clonal amplification of either CD3(+) cytotoxic T-lymphocytes or CD3(-) natural killer cells. This chapter focuses on the T-cell form of LGL leukemia. Clinical features include neutropenia, anemia, and rheumatoid arthritis. LGL leukemia is thought to arise from chronic antigenic stimul...
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We studied 25 T-cell chronic lymphocytic leukemia (T-CLL) cases collected over a 15-year period. Immunophenotypic analysis was performed in each case; 12 cases were evaluated by cytogenetics, and gene rearrangement studies were performed in 14 cases. The median age was 57 years with a male predominance (M:F, 15:10). The median presenting lymphocyte count was 36.3 x 10(9)/L (range, 3.9 to 438 x ...
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We report here a case of a 59-yr-old man with CD4(+) T-cell large granular lymphocytic leukemia (T-LGL). Peripheral blood examination indicated leukocytosis (45×10(9) cells/L) that consisted of 34% neoplastic lymphoid cells. Other laboratory results indicated no specific abnormalities except for serum antinuclear antibody titer (1:640), glucose (1.39 g/L), and hemoglobin A1c (7.7%) levels. Comp...
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OBJECTIVES The aim of this retrospective study was to investigate the results of T-cell large granular lymphocytic leukemia treatment with fludarabine by assessing the complete hematologic response, the complete molecular response, progression-free survival, and overall survival. METHODS We evaluated the records of six patients with T-cell large granular lymphocytic leukemia who were treated ...
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Do cy-togenetic abnormalities precede morphologic abnormalities in a developing malignant condition? Eur J Haematol 2007;78: 152-6. 4. Wong KF, Kwong YL. Isochromosome 8q is a marker of secondary acute myeloid leukemia. Deletion of 6q16-q21 in human lymphoid malignancies: a mapping and deletion analysis. et al. 6q deletion detected by fluorescence in situ hybridization using bacterial artificia...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2011
ISSN: 0002-9173,1943-7722
DOI: 10.1309/ajcptffq18jmykdf