Clinical Relevance of Serum Nortriptyline and 10-Hydroxy-Nortriptyline Measurements in the Depressed Elderly: A Multicenter Pharmacokinetic and Pharmacodynamic Study
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منابع مشابه
Pharmacokinetic interaction between nevirapine and nortriptyline in rats: inhibition of nevirapine metabolism by nortriptyline.
One of the most frequent comorbidities of HIV infection is depression, with a lifetime prevalence of 22 to 45%. Therefore, it was decided to study a potential pharmacokinetic interaction between the nonnucleoside reverse transcriptase inhibitor nevirapine (NVP) and the tricyclic antidepressant nortriptyline (NT). NVP and NT were administered to rats either orally, intraduodenally, or intravenou...
متن کاملPlasma concentrations of nortriptyline and its 10-hydroxy metabolite in depressed patients--relationship to the debrisoquine hydroxylation metabolic ratio.
In 20 depressed patients treated with nortriptyline (NT) there was a significant relationship between the plasma concentration of NT and the debrisoquine metabolic ratio (rs = 0.77; P less than 0.01). (The debrisoquine test was performed after stopping NT treatment). This is in agreement with the hypothesis that the hydroxylations of NT and debrisoquine are mediated by similar enzymatic mechani...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 1996
ISSN: 0893-133X
DOI: 10.1016/0893-133x(95)00142-z