Clinical Trial Designs for Predictive Biomarker Validation: Theoretical Considerations and Practical Challenges
نویسندگان
چکیده
منابع مشابه
Clinical trial designs for predictive biomarker validation: theoretical considerations and practical challenges.
PURPOSE Biomarkers can add substantial value to current medical practice by providing an integrated approach to prediction using the genetic makeup of the tumor and the genotype of the patient to guide patient-specific treatment selection. We discuss and evaluate various clinical trial designs for the validation of biomarker-guided therapy. METHODS Designs for predictive marker validation are...
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ژورنال
عنوان ژورنال: Journal of Clinical Oncology
سال: 2009
ISSN: 0732-183X,1527-7755
DOI: 10.1200/jco.2009.22.3701