Clustering of gene ontology terms in genomes

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Clustering of gene ontology terms in genomes.

Although protein coding genes occupy only a small fraction of genomes in higher species, they are not randomly distributed within or between chromosomes. Clustering of genes with related function(s) and/or characteristics has been evident at several different levels. To study how common the clustering of functionally related genes is and what kind of functions the end products of these genes ar...

متن کامل

Spectral Clustering Gene Ontology Terms to Group Genes by Function

With the invention of biotechnological high throughput methods like DNA microarrays, biologists are capable of producing huge amounts of data. During the analysis of such data the need for a grouping of the genes according to their biological function arises. In this paper, we propose a method that provides such a grouping. As functional information, we use Gene Ontology terms. Our method clust...

متن کامل

The Compositional Structure of Gene Ontology Terms

An analysis of the term names in the Gene Ontology reveals the prevalence of substring relations between terms: 65.3% of all GO terms contain another GO term as a proper substring. This substring relation often coincides with a derivational relationship between the terms. For example, the term regulation of cell proliferation (GO:0042127) is derived from the term cell proliferation (GO:0008283)...

متن کامل

Measuring semantic similarity between Gene Ontology terms

Many bioinformatics applications would benefit from comparing proteins based on their biological role rather than their sequence. This manuscript adds two new contributions. First, a study of the correlation between Gene Ontology (GO) terms and family similarity demonstrates that protein families constitute an appropriate baseline for validating GO similarity. Secondly, we introduce GraSM, a no...

متن کامل

Centralized Clustering Method To Increase Accuracy In Ontology Matching Systems

Ontology is the main infrastructure of the Semantic Web which provides facilities for integration, searching and sharing of information on the web. Development of ontologies as the basis of semantic web and their heterogeneities have led to the existence of ontology matching. By emerging large-scale ontologies in real domain, the ontology matching systems faced with some problem like memory con...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Gene

سال: 2014

ISSN: 0378-1119

DOI: 10.1016/j.gene.2014.06.060