Clustering protein environments for function prediction: finding PROSITE motifs in 3D
نویسندگان
چکیده
منابع مشابه
Automatic Construction of 3D Structural Motifs for Protein Function Prediction
Structural genomics initiatives are on the verge of generating a vast number of protein structures. The biological roles for many of these proteins are still unknown, and high-throughput methods for determining their function are necessary. Understanding the function of these proteins will have profound impact in drug development and protein engineering. Current methods for protein function pre...
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Determining the function of all proteins is a recurring theme in modern biology and medicine, but the sheer number of proteins makes experimental approaches impractical. For this reason, current efforts have considered in silico function prediction in order to guide and accelerate the function determination process. One approach to predicting protein function is to search functionally uncharact...
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The identification of small structural motifs and their organization into larger subassemblies is of fundamental interest in the analysis, prediction and design of 3D structures of large RNAs. This problem has been studied only sparsely, as most of the existing work is limited to the characterization and discovery of motifs in RNA secondary structures. We present a novel geometric method for th...
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MOTIVATION Function inference from structure is facilitated by the use of patterns of residues (3D motifs), normally identified by expert knowledge, that correlate with function. As an alternative to often limited expert knowledge, we use machine-learning techniques to identify patterns of 3-10 residues that maximize function prediction. This approach allows us to test the assumption that resid...
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Determining the function of proteins is a problem with immense practical impact on the identification of inhibition targets and the causes of side effects. Unfortunately, experimental determination of protein function is expensive and time consuming. For this reason, algorithms for computational function prediction have been developed to focus and accelerate this effort. These algorithms are co...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2007
ISSN: 1471-2105
DOI: 10.1186/1471-2105-8-s4-s10