Coagulopathy and traumatic shock: Characterizing hemostatic function during the critical period prior to fluid resuscitation

Hemostatic resuscitation for acute traumatic coagulopathy

Trauma resuscitation paradigms have changed considerably over the last twenty years. Originally, the goal was to normalize a blood pressure as quickly as possible. Large volume crystalloid resuscitation was used to accomplish this. Standard therapy was that any patient with suspected bleeding received a two liter crystalloid bolus as initial therapy. It was often repeated and blood transfusion ...

Hemostatic resuscitation in traumatic hemorrhagic shock: case report.

BACKGROUND AND OBJECTIVES The aim of this paper is to report a case in which the damage control resuscitation (DCR) approach was successfully used to promote hemostatic resuscitation in a polytraumatized patient with severe hemorrhagic shock. CASE REPORT Female patient, 32 years of age, with severe hemorrhagic shock due to polytrauma with hip fracture, who developed acidosis, coagulopathy, an...

Macro-hemodynamic targets and hemostatic effects of fluid resuscitation during experimental hemorrhagic shock

Hemorrhage, Shock, and Fluid Resuscitation

A Role for Vasopressin during Resuscitation of Traumatic Shock

In the past few years, arginine vasopressin (AVP) has emerged as a rational alternative to catecholamines for the hemodynamic support of refractory vasodilatory shock and cardiopulmonary arrest. The therapeutic potential of AVP in traumatic shock is now being evaluated. Our laboratory investigations have revealed an apparent benefit of AVP when compared to standard fluid resuscitation in clinic...